Selectina e soluble séricas materna y neonatal en preeclámpticas y embarazadas normotensas
[Maternal and neonatal serum soluble e-selectin in preeclamptic patients and normotensive pregnant women]Mayra Sarmiento Piña1, Eduardo Reyna-Villasmil1, Jorly Mejía-Montilla2, Nadia Reyna-Villasmil2, Duly Torres-Cepeda1, Martha Rondón-Tapia1, Carlos Briceño-Pérez2
1. Servicio de Ginecología y Obstetricia, Hospital Central “Dr Urquinaona, Maracaibo, Venezuela; 2. Facultad de Medicina, Universidad del Zulia, Maracaibo, Venezuela;
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Resumen
OBJETIVO: Comparar las concentraciones séricas maternas y neonatales de selectina E soluble en preeclámpticas y embarazadas normotensas. METODOLOGÍA: Se realizó un estudio de casos y controles en 180 embarazadas (grupo A; 90 preeclámpticas y grupo B; 90 embarazadas normotensas) que asistieron al Hospital Central “Dr. Urquinaona”, Venezuela. Se evaluaron las características generales, parámetros de laboratorio y concentraciones séricas maternas - neonatales de selectina E soluble. RESULTADOS: Comparado con las pacientes del grupo B, las pacientes del grupo A presentaron concentraciones de selectina E soluble más altas (p < 0,0001). Sin embargo, los neonatos de este grupo mostraron concentraciones significativamente más bajas (p < 0,0001). Al comparar las concentraciones maternas y neonatales en cada uno de los grupos no se encontraron diferencias significativas entre las concentraciones maternas neonatales en el grupo A (p = 0,6849) pero si se encontraron diferencias significativas en los valores del grupo B (p < 0,0001). CONCLUSIÓN: Las preeclámpticas presentan concentraciones de selectina E soluble más elevadas comparadas con las embarazadas normotensas sanas. No obstante, sus neonatos presentan concentraciones significativamente más bajas comparadas con los neonatos de las embarazadas normotensas.
Abstract
OBJECTIVE: To compare maternal and neonatal serum concentrations of soluble E-selectin in preeclamptic and normotensive pregnant. METHODOLOGY: A case-control study was conducted in 180 pregnant women (group A, 90 preeclamptic and group B, 90 normotensive pregnant women) who attended the Central Hospital "Dr. Urquinaona", Venezuela. The general characteristics, laboratory parameters and maternal-neonatal serum concentrations of soluble E-selectin were evaluated. RESULTS: Compared with patients in group B, patients in group A had higher soluble selectin E concentrations (p <0.0001). However, neonates in this group showed significantly lower concentrations (p <0.0001). When comparing maternal and neonatal concentrations in each of the groups, no significant differences were found between neonatal maternal concentrations in group A (p = 0.6849) but significant differences were found in group B values (p <0.0001). CONCLUSION: Preeclamptic patients have higher soluble E-selectin concentrations compared to healthy normotensive pregnant women. However, their neonates show significantly lower concentrations compared with neonates of normotensive pregnant women.
Citas
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